METHODS FOR PREPARING COMPLEX MULTIVALENT IMMUNOGENIC CONJUGATES

Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group...

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1. Verfasser: LEE, Che-Hung Robert
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Methods for preparing complex multivalent immunogenic conjugates that include simultaneously reacting a plurality or immunogenic-distinct polysaccharides with at least one protein to make the complex multivalent immunogenic conjugates. The simultaneous reaction involves reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant.