ANTI-TNF-ALPHA/CXCL10 DOUBLE-TARGETING ANTIBODY AND USE THEREOF

The present invention relates to a TNF-± (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXC...

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Bibliographische Detailangaben
Hauptverfasser:	LEE, EUN YOUNG, LEE, DONG HEE, PARK, SO-HYUN, PARK, BUMAN, JANG, MYEOUNG HEE, YUN, SEON HA, KIM, DONG JIN, LEE, KE SE, KIM, HEE CHAN, SHIN, KI CHUL, KANG, HEUN-SOO, YOO, SEOK HO, LEE, HYUN JU, KIM, KYUNG JIN, JANG, SEIL, LEE, EUN BONG, SONG, YEONG WOOK, PARK, YOUNG WOO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to a TNF-± (tumor necrosis factor-alpha)/CXCL-10 (C-X-C motif chemokine 10) double targeting antibody based on the IgG format. Specifically, it was verified that an antibody, in which scFv having a heavy chain variable domain and a light chain variable domain of the CXCL10 specific antibody links to the C-terminus of the heavy chain constant domain of the TNF-± specific antibody, is a bispecific antibody that effectively binds to both TNF-± and CXCL10, and thus the antibody can be useful as a double targeting antibody capable of identifying TNF-±/CXCL10. A composition of the present invention comprises a TNF-±/CXCL-10 double targeting antibody which effectively binds to both TNF-± and CXCL10. The double targeting antibody of the present invention has excellent TNF-± inhibitory activity and osteoclast differentiation inhibitory activity compared with the TNF-± or CXCL10 single targeting antibody. The composition of the present invention can be used in preventing or treating immunological disease.