THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS

THIAZOLE-SUBSTITUTED AMINOHETEROARYLS AS SPLEEN TYROSINE KINASE INHIBITORS

The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and...

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Bibliographische Detailangaben
Hauptverfasser: SPENCER, KERRIE, B, ANDRESEN, BRIAN, M, MILLER, THOMAS, A, LIU, YUAN, WOO, HYUN CHONG, ROBICHAUD, JOEL, S, GUAY, DANIEL, DUBOIS, BYRON, WANG, LIPING, ELLIS, JOHN MICHAEL, ALTMAN, MICHAEL, D, DENG, QIAOLIN, ANTHONY, NEVILLE, J, CHILDERS, KALEEN, K, MACHACEK, MICHELLE, R, LEBRUN, MARIE-EVE, DONOFRIO, ANTHONY, ROMEO, ERIC, T, NORTHRUP, ALAN, B, GRIMM, JONATHAN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention provides certain thiazole-substituted aminoheteroaryl compounds of the Formula (I) or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, Y1, Y2, Y3, Y4, and R4 are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk).