ANTIMICROBIAL CATIONIC POLYCARBONATES

Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end grou...

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Hauptverfasser: COADY, Daniel Joseph, DIPIETRO, Richard Anthony, ENGLER, Amanda Catherine, TAN, Jeremy P.K, ONG, Zhan-Yuin, HEDRICK, James Lupton, YANG, Yi Yan, NG, Victor W.L
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups. The end groups can comprise a covalently bound form of biologically active compound such as cholesterol. Other antimicrobial cationic polymers have a random copolycarbonate chain comprising a minor mole fraction of hydrophobic repeat units bearing a covalently bound form of a vitamin E and/or vitamin D2. The cationic polymers exhibit high activity and selectivity against Gram-negative and Gram-positive microbes and fungi.