METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE

METHODS OF ACUTE RESTORATION OF VASCULAR COMPLIANCE

Disclosed herein is a compound comprising a 4-amino-1,8-naphthalimide for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood v...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: DOWNEY, Therese, J, UTECHT, Ronald, E, HABERER, Barbara, R
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed herein is a compound comprising a 4-amino-1,8-naphthalimide for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque, as well as acutely restoring the vascular compliance at the treatment site of the blood vessel, while maintaining luminal gain during angioplasty . Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.