COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY

The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising...

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Bibliographische Detailangaben
Hauptverfasser:	DAI, XING, GRESHOCK, THOMAS, STEVENSON, HEATHER, LIU, HONG, SANDERS, JOHN, MILLER, MICHAEL, MCCAULEY, JOHN, A, KERN, JONATHAN, HARRIS, JOEL, M, BASU, KALLOL, SCOTT, JACK, DEMONG, DUANE, STAMFORD, ANDREW, W, POIRIER, MARC, NEUSTADT, BERNARD
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.