METHOD FOR PREDICTING RESPONSIVENESS TO COMPOUND INHIBITING MAPK SIGNAL TRANSDUCTION PATHWAY

Provided are a method for predicting sensitivity to a molecularly targeted drug, a method for selecting patients for which administration of the drug is determined to have a high probability of success, and a reagent used in said methods. Specifically provided are: a method for using a biological sa...

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Bibliographische Detailangaben
1. Verfasser:	KIGA, Masaki
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are a method for predicting sensitivity to a molecularly targeted drug, a method for selecting patients for which administration of the drug is determined to have a high probability of success, and a reagent used in said methods. Specifically provided are: a method for using a biological sample derived from a cancer patient in order to predict responsiveness to cancer treatment by a compound that inhibits the mitogen-activated protein kinase (MAPK) signal transduction pathway, said method being characterized by measuring whether [beta]-catenin in the biological sample has at least one mutation selected from the group consisting of (i) an activating mutation and (ii) a mutation in which an aspartic acid residue is substituted by a serine residue at the 287 position; a method for selecting a subject for cancer treatment using said compound; a cancer treatment method that includes administering the compound to a patient selected by the aforementioned method; and a reagent used in said methods.