2,6,7,8 SUBSTITUTED PURINES AS HDM2 INHIBITORS

The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	MARTINEZ, MICHELLE, DINSMORE, CHRISTOPHER, CHRISTOPHER, MATTHEW, P, PAN, WEIDONG, VOSS, MATTHEW ERNST, KURISSERY, ANTHAPPAN TONY, SUN, BINYUAN, PANDA, JAGANNATH, BOGEN, STEPHANE, L, THOMPSON, CHRISTOPHER FRANCIS, CAMMARANO, CAROLYN MICHELE, SHIZUKA, MANAMI, TROTTER, B. WESLEY, REUTERSHAN, MICHAEL HALE, MACHACEK, MICHELLE, YANG, LIPING, NAIR, LATHA, G, WANG, YAOLIN, FRADERA LLINAS, FRANCESC XAVIER, DOLL, RONALD, J, STEINHUEBEL, DIETRICH, P, LI, CHAOMIN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The present invention provides 2,6,7,8 Substituted Purines as described herein or a pharmaceutically acceptable salt thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.