ISOXAZOLE DERIVATIVES AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS

The present invention relates to isoxazole derivatives of formula (I) and their synthesis as inhibitors of leukotriene (LT) biosynthesis by modulating the activity of 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP). The present invention also relates to pharmaceutical compositions...

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Bibliographische Detailangaben
Hauptverfasser:	CELIKOGLU, ERSAN, VOELKER, SUSANNA, ALTENHOFEN, WOLFRAM, EREN, GOKCEN, LEVENT, SERKAN, BANOGLU, ERDEN, WERZ, OLIVER, CALISKAN, BURCU, GARSCHA, ULRIKE
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to isoxazole derivatives of formula (I) and their synthesis as inhibitors of leukotriene (LT) biosynthesis by modulating the activity of 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP). The present invention also relates to pharmaceutical compositions comprising these isoxazole derivatives, as well as, their use for treating leukotriene-related inflammatory disorders such as bronchial asthma, chronic obstructive pulmonary disease (COPD), allergic rhinitis, psoriasis, pruritus, arthritis, atherosclerosis, cancer and other inflammatory and autoimmune ailments.