GEL COMPOSITIONS

The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycol in an amount comprised from 20 t...

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Bibliographische Detailangaben
Hauptverfasser: ROIG CARRERAS, MANEL, GARCÍA MONTOYA, ENCARNA, GONZÁLEZ OJER, CARLOS, SUÑÉ NEGRE, JOSEP M, TICÓ GRAU, JOSEP RAMON, DA COSTA MARTINS, RAQUEL MARIA, PÉREZ LOZANO, PILAR, MIÑARRO CARMONA, MONTSERRAT, SÁNCHEZ PORQUERES, NATALIA
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention provides a gel combination comprising: polycarbophil in an amount comprised from 1 to 5% by weight; polyvinylpirrolidone in an amount comprised from 4 to 8% by weight; glycerine in an amount comprised from 1 to 10% by weight; and propyleneglycol in an amount comprised from 20 to 40% by weight; wherein: the weight ratio between polyvinylpirrolidone:polycarbophil is comprised between 1:1 and 4:1, the weight ratio between glycerine:polycarbophil is comprised from 0.5:1 to 2:1, and the weight ratio propyleneglycol:polycarbophil is comprised from 8:1 to 20:1. The invention also provides transparent compositions comprising such gel combinations as well as processes for their preparation and the use thereof as a medicament. Due to the specific excipients, % by weight, and weight ratios forming the combination, the resulting compositions show a high bioadhesivity and bioavailablity of the active ingredient, without toxic adverse effects.