PROCESS FOR MAKING REVERSE TRANSCRIPTASE INHIBITORS

The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting...

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Bibliographische Detailangaben
Hauptverfasser: MANGION, IAN, JEON, INGYU, SHERRY, BENJAMIN, D, QIAN, GANG, GAUTHIER, DONALD, R, CAO, YANG, ITOH, TETSUJI
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention is directed to a novel process for synthesizing 3-(substituted phenoxy)-1-[(5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl])-pyridin-2(1H)-one derivatives. The compounds synthesized by the processes of the invention are HIV reverse transcriptase inhibitors useful for inhibiting reverse transcriptase, HIV replication and the treatment of human immunodeficiency virus infection in humans.