METHOD TO OBTAIN ANTIGEN-SPECIFIC HUMAN ANTIBODIES USING IN VITRO IMMUNISATION

METHOD TO OBTAIN ANTIGEN-SPECIFIC HUMAN ANTIBODIES USING IN VITRO IMMUNISATION

A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of olig...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SAVATIER, Alexandra, VOLLAND, Hervé, WIJKHUISEN, Anne, LEONETTI, Michel, LAMOURETTE, Patricia
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of oligomerization and (ii) a ligand of a surface molecule specific to the antigen presenting cells; a method for producing antigen-specific human antibodies derived from said in vitro immunization method.