Enantiopure tetrasubstituted pyrrolidines as scaffolds for proteasome inhibitors and medicinal applications thereof

The present invention refers to compounds of general formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and the use thereof for the treatment and/or chemoprevention of cancer, hematological malignancy, proliferative diseases, autoimmune diseas...

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Bibliographische Detailangaben
Hauptverfasser:	BELLO IGLESIAS, TAMARA, MASDEU MARGALEF, MARÍA DEL CARMEN, RETAMOSA HERNANDEZ, MARÍA DE GRACIA, LARUMBE GARATA, AMAIA, COSSIO MORA, FERNANDO PEDRO, ZUBIA OLASCOAGA, AIZPEA, VARA SALAZAR, YOSU ION, ALDABA AREVALO, ENEKO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention refers to compounds of general formula (I): as well as to a method for their preparation, pharmaceutical compositions comprising the same, and the use thereof for the treatment and/or chemoprevention of cancer, hematological malignancy, proliferative diseases, autoimmune diseases, neurodegenerative diseases and viral infections.