N-SUBSTITUTED 3,4-BIS(CATECHOL)PYRROLE COMPOUNDS, THEIR PREPARATION AND USE IN THE TREATMENT OF CANCER

The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n 1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO2, CF3, CCI3, CN, CO2H, (C O)...

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Bibliographische Detailangaben
Hauptverfasser: ACHAB, MARIA, BENECHIE, MICHEL, EGOROV, MAXIM, DELPECH, BERNARD, BIGNON, JÉRÔME, COLLIN, PASCAL, BAKALA, JOANNA, THOISON, ODILE
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present invention relates to a compound of formula (I) in which: -m is an integer from 0 to 3, preferably from 0 to 2; n is an integer from 0 to 3, preferably from 0 to 2; m+n 1; EAG is an electro-attractive group chosen independently from among a halogen atom, an NO2, CF3, CCI3, CN, CO2H, (C O)NR2, CH NR, (C S)OR, (C O)SR, CS2R, SO2R, SO2NR2, SO3R, P(O)(OR)2, P(O)(R)2, B(OR)2 group where R is a (C1-C6) alkyl radical, a phenyl group or a hydrogen atom; A is a saturated or unsaturated, linear or branched hydrocarbon chain including 1 to 10 atoms of carbon; and R1 and R2 each represent independently from one another a hydrogen atom, a CO-(Ci-C6)-alkyl, (C1-C6) alkyl, phenyl or phenyl-(C1-C6)-alkyl group, in which R1 and R2 form, together with the nitrogen atom they carry, a 5- to 15-member heterocycle, optionally substituted by a (C1-C6) alkyl group; including its stereoisomers and the mixtures thereof, or a pharmaceutically acceptable salt of same.