INHIBITORS OF IRAK4 ACTIVITY

The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of F...

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Bibliographische Detailangaben
Hauptverfasser:	YET, Larry, BRUMFIELD, Stephanie, YANG, Jinhai, KOZLOWSKI, Joseph, A, SEGANISH, W. Michael, WONG, Michael, K. C, MCELROY, William, T, HO, Ginny Dai, HARDING, James, P., III, YU, Wensheng, HERR, R. Jason, TULSHIAN, Deen, B, LAVEY, Brian, J
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds which modulate interleukin-1 (IL-1) receptor-associated kinase 4 (IRAK4) and are useful in the prevention or treatment of inflammatory, cell proliferative and immune-related conditions and diseases. Specifically, provided herein are inhibitors of IRAK4 of Formula I and pharmaceutical compositions comprising such inhibitors, as well as methods therewith for treating IRAK4-mediated or -associated conditions or diseases.