METHOD OF PRODUCING SELF-ASSEMBLING PEPTIDE DERIVATIVE

METHOD OF PRODUCING SELF-ASSEMBLING PEPTIDE DERIVATIVE

An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employ...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: YOKOYAMA, Yasuhiro, YOKOI, Hidenori, NAGANO, Toyohiro, NAKAMURA, Daisuke, MATSUYAMA, Keisuke, YAMAMOTO, Kenichiro, ANZAI, Kinsei, KODAMA, Kazuya
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:An object of the present invention is to provide a process capable of producing a self-assembling peptide derivative that is useful in the fields of regenerative medicine and surgery in large quantities and in an economical and efficient manner. In particular, provided is a production process employing a combination of (i) a step of convergently constructing a sequence with use of a common repeating unit consisting of a specific amino acid sequence and (ii) a step of first isolating the peptide derivative as a disulfuric acid salt, a tetramethanesulfonic acid salt or a tetra(trifluoroacetic acid (TFA) salt), and then subjecting the peptide salt to a salt exchange reaction to yield a tetrahydrochloric acid salt.