SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS
The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds fo...
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| creator | SCHELL, ADAM, J TAOKA, BRANDON, M KNOWLES, SANDRA LEE ALTMAN, MICHAEL, D JEWELL, JAMES, P ELLIS, JOHN, MICHAEL DESCHENES, DENIS NORTHHRUP, ALAN, B ROBICHAUD, JOEL REUTERSHAN, MICHAEL, H FISCHER, CHRISTIAN HAIDLE, ANDREW, M CHRISTOPHER, MATTHEW KATTAR, SOLOMON, D ZHOU, HUA BURCH, JASON DONOFRIO, ANTHONY BLOUIN, MARC |
| description | The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase. |
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The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2015</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151216&DB=EPODOC&CC=EP&NR=2863916A4$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20151216&DB=EPODOC&CC=EP&NR=2863916A4$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHELL, ADAM, J</creatorcontrib><creatorcontrib>TAOKA, BRANDON, M</creatorcontrib><creatorcontrib>KNOWLES, SANDRA LEE</creatorcontrib><creatorcontrib>ALTMAN, MICHAEL, D</creatorcontrib><creatorcontrib>JEWELL, JAMES, P</creatorcontrib><creatorcontrib>ELLIS, JOHN, MICHAEL</creatorcontrib><creatorcontrib>DESCHENES, DENIS</creatorcontrib><creatorcontrib>NORTHHRUP, ALAN, B</creatorcontrib><creatorcontrib>ROBICHAUD, JOEL</creatorcontrib><creatorcontrib>REUTERSHAN, MICHAEL, H</creatorcontrib><creatorcontrib>FISCHER, CHRISTIAN</creatorcontrib><creatorcontrib>HAIDLE, ANDREW, M</creatorcontrib><creatorcontrib>CHRISTOPHER, MATTHEW</creatorcontrib><creatorcontrib>KATTAR, SOLOMON, D</creatorcontrib><creatorcontrib>ZHOU, HUA</creatorcontrib><creatorcontrib>BURCH, JASON</creatorcontrib><creatorcontrib>DONOFRIO, ANTHONY</creatorcontrib><creatorcontrib>BLOUIN, MARC</creatorcontrib><title>SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS</title><description>The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2015</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAJDnUKDvEMCQ1xdVEIiAzydPH0c1UIDvBxdfVTCIkM8g8G8b09_RyDXRU0giuzNRU8_Tw8nTxD_IOCeRhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJvGuAkYWZsaWhmaOJMRFKAAO7Kd0</recordid><startdate>20151216</startdate><enddate>20151216</enddate><creator>SCHELL, ADAM, J</creator><creator>TAOKA, BRANDON, M</creator><creator>KNOWLES, SANDRA LEE</creator><creator>ALTMAN, MICHAEL, D</creator><creator>JEWELL, JAMES, P</creator><creator>ELLIS, JOHN, MICHAEL</creator><creator>DESCHENES, DENIS</creator><creator>NORTHHRUP, ALAN, B</creator><creator>ROBICHAUD, JOEL</creator><creator>REUTERSHAN, MICHAEL, H</creator><creator>FISCHER, CHRISTIAN</creator><creator>HAIDLE, ANDREW, M</creator><creator>CHRISTOPHER, MATTHEW</creator><creator>KATTAR, SOLOMON, D</creator><creator>ZHOU, HUA</creator><creator>BURCH, JASON</creator><creator>DONOFRIO, ANTHONY</creator><creator>BLOUIN, MARC</creator><scope>EVB</scope></search><sort><creationdate>20151216</creationdate><title>SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS</title><author>SCHELL, ADAM, J ; TAOKA, BRANDON, M ; KNOWLES, SANDRA LEE ; ALTMAN, MICHAEL, D ; JEWELL, JAMES, P ; ELLIS, JOHN, MICHAEL ; DESCHENES, DENIS ; NORTHHRUP, ALAN, B ; ROBICHAUD, JOEL ; REUTERSHAN, MICHAEL, H ; FISCHER, CHRISTIAN ; HAIDLE, ANDREW, M ; CHRISTOPHER, MATTHEW ; KATTAR, SOLOMON, D ; ZHOU, HUA ; BURCH, JASON ; DONOFRIO, ANTHONY ; BLOUIN, MARC</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2863916A43</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2015</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHELL, ADAM, J</creatorcontrib><creatorcontrib>TAOKA, BRANDON, M</creatorcontrib><creatorcontrib>KNOWLES, SANDRA LEE</creatorcontrib><creatorcontrib>ALTMAN, MICHAEL, D</creatorcontrib><creatorcontrib>JEWELL, JAMES, P</creatorcontrib><creatorcontrib>ELLIS, JOHN, MICHAEL</creatorcontrib><creatorcontrib>DESCHENES, DENIS</creatorcontrib><creatorcontrib>NORTHHRUP, ALAN, B</creatorcontrib><creatorcontrib>ROBICHAUD, JOEL</creatorcontrib><creatorcontrib>REUTERSHAN, MICHAEL, H</creatorcontrib><creatorcontrib>FISCHER, CHRISTIAN</creatorcontrib><creatorcontrib>HAIDLE, ANDREW, M</creatorcontrib><creatorcontrib>CHRISTOPHER, MATTHEW</creatorcontrib><creatorcontrib>KATTAR, SOLOMON, D</creatorcontrib><creatorcontrib>ZHOU, HUA</creatorcontrib><creatorcontrib>BURCH, JASON</creatorcontrib><creatorcontrib>DONOFRIO, ANTHONY</creatorcontrib><creatorcontrib>BLOUIN, MARC</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHELL, ADAM, J</au><au>TAOKA, BRANDON, M</au><au>KNOWLES, SANDRA LEE</au><au>ALTMAN, MICHAEL, D</au><au>JEWELL, JAMES, P</au><au>ELLIS, JOHN, MICHAEL</au><au>DESCHENES, DENIS</au><au>NORTHHRUP, ALAN, B</au><au>ROBICHAUD, JOEL</au><au>REUTERSHAN, MICHAEL, H</au><au>FISCHER, CHRISTIAN</au><au>HAIDLE, ANDREW, M</au><au>CHRISTOPHER, MATTHEW</au><au>KATTAR, SOLOMON, D</au><au>ZHOU, HUA</au><au>BURCH, JASON</au><au>DONOFRIO, ANTHONY</au><au>BLOUIN, MARC</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS</title><date>2015-12-16</date><risdate>2015</risdate><abstract>The invention provides certain substituted pyridines of the Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, Rcy, Cy, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions mediated by Spleen Tyrosine Kinase (Syk) kinase.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | SUBSTITUTED PYRIDINE SPLEEN TYROSINE KINASE (Syk) INHIBITORS |
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