PYRROLE [2, 1-F][1, 2, 4]TRIAZINE DERIVATIVE AND ANTITUMOR EFFECT THEREOF

PYRROLE [2, 1-F][1, 2, 4]TRIAZINE DERIVATIVE AND ANTITUMOR EFFECT THEREOF

Disclosed are a pyrrolo[2,1-f][1,2,4]triazine derivative of Formula (I) and use thereof for treating tumors. The compound has remarkable antiproliferative activity for a variety of human tumor cell lines, and is useful for treating cancers, and especially solid tumors such as gastric cancer, lung ca...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: ZHU, CHUNRUI, SHU, QINGNING, YANG, MINMIN, WU, XIHAN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Disclosed are a pyrrolo[2,1-f][1,2,4]triazine derivative of Formula (I) and use thereof for treating tumors. The compound has remarkable antiproliferative activity for a variety of human tumor cell lines, and is useful for treating cancers, and especially solid tumors such as gastric cancer, lung cancer, liver cancer, breast cancer, colon cancer, prostatic cancer, and oral cancer.