Process for the preparation of esomeprazole magnesium dihydrate

Process for the preparation of esomeprazole magnesium dihydrate

A process for preparing (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole comprising oxidizing 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio-1H-benzimidazole in the absence of a base and in the presence of an oxidizing agent and a chiral titani...

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Bibliographische Detailangaben
Hauptverfasser: BANGALORE, SUMANA, GOPALAKRISHNA, RAO, DHARMARAJ RAMACHANDRA, SRINIVAS, PATHI, L, KANKAN, RAJENDRA NARAYANRAO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:A process for preparing (S)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazole comprising oxidizing 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]thio-1H-benzimidazole in the absence of a base and in the presence of an oxidizing agent and a chiral titanium complex.