CROSSLINKED HYALURONAN DERIVATIVE, METHOD OF PREPARATION THEREOF, HYDROGEL AND MICROFIBERS BASED THEREON

CROSSLINKED HYALURONAN DERIVATIVE, METHOD OF PREPARATION THEREOF, HYDROGEL AND MICROFIBERS BASED THEREON

The invention relates to a crosslinked hyaluronan derivative in the form of a hydrogel or microfibers, and to a method of preparation thereof, consisting in a C-C coupling reaction. The C-C coupling reaction is performed via reaction of a hyaluronan derivative carrying a terminal aryl-halide and/or...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: VELEBNY, VLADIMIR, JOUKLOVA, ZUZANA, PRIKOPOVA, EVA, HUERTA-ANGELES, GLORIA
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to a crosslinked hyaluronan derivative in the form of a hydrogel or microfibers, and to a method of preparation thereof, consisting in a C-C coupling reaction. The C-C coupling reaction is performed via reaction of a hyaluronan derivative carrying a terminal aryl-halide and/or aryl-borate group, and a hyaluronan derivative carrying an alkenyl or alkynyl group, in water, phosphates buffer or a mixture of an organic acid and an alcohol, and in the presence of a palladium active catalyst. The palladium active catalyst may be e.g. a complex of palladium (II) acetate and an inorganic or organic base, or a complex of palladium (II) and 2-amino-4,6-dihydroxypyrimidine.