TAMPER RESISTANT IMMEDIATE RELEASE FORMULATIONS

Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising an inert excipient and an active agent, wherein the inert excipient is layered with the active agent; and (ii) a material that is sensi...

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Bibliographische Detailangaben
Hauptverfasser:	KUPPER, Robert, Joe, MANCINELLI, Vincent, ADJEI, Akwete, L, CHEN, Sibao
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed in certain embodiments is an immediate release solid oral dosage form comprising a plurality of particles, each particle comprising: (i) a core comprising an inert excipient and an active agent, wherein the inert excipient is layered with the active agent; and (ii) a material that is sensitive to acidic pH layered on the core; wherein the plurality of particles are dispersed in a matrix comprising a gelling agent; and wherein the dosage form releases at least about 70% of the active agent within 45 minutes as measured by in-vitro dissolution in a USP Apparatus 2 (paddle) at 50 rpm in 500 ml 0.1N HCl at 37° C.