Engine supporting structure for saddle-ride type vehicle

To improve appearance quality of a frame while capable of providing a member for supporting an engine on an inner side of the frame, in an engine supporting structure for a saddle-ride type vehicle. An engine supporting structure for a saddle-ride type vehicle is configured such that an engine is supported from above in substantially a center position between a head pipe 13 and a pivot in a side view, on a pair of right and left main frames 14, 14 that are branched to right and left from the head pipe 13 and that extend rearward. Only inner surfaces 78 in a vehicle width direction of the right and left main frames 14, 14 are formed with a pair of left front mounting portions 79 and a pair of right rear mounting portions 80, that project inward in the vehicle width direction, respectively, the front mounting portions 79 and the rear mounting portions 80 are mounted with engine hangers 28, 28 that extend downward, and the engine is supported through the engine hangers 28, 28.