Molecular analysis device

A molecular analysis device comprises a substrate with a waveguide on the substrate comprising a coupling means configured for coupling a predetermined frequency range of laser radiation into the waveguide and comprising a planar integrating element with a filter or reflector element adjacent to of the integrating element, the waveguide and the planar integrating element having a height such that they are single mode out-of- plane. At least one metallic nanostructure is disposed on top or adjacent to the planar integrating element, configured such that the field intensity and the gradient of the laser radiation, that is coupled into the waveguide, are enhanced over a sufficiently large volume around the nanostructure to simultaneously cause plasmonic based optical trapping of analytes in a medium, and plasmonic based excitation of the particles to produce Raman scattered radiation. A Raman scattered radiation collection means is disposed on the substrate for collecting said Raman scattered radiation produced by the particles.