MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS
There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or...
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| creator | BLANCO APARICIO, Carmen PASTOR FERNÁNDEZ, Joaquín RODRÍGUEZ HERGUETA, Antonio ÁLVAREZ ESCOBAR, Rosa María MARTÍN HERNANDO, Jose Ignacio RIESCO FAGUNDO, Rosario Concepción CEBRIÁN MUÑOZ, David Álvaro GARCÍA GARCÍA, Ana Belén |
| description | There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds. |
| format | Patent |
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The invention also relates to combinations containing such compounds.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2021</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211229&DB=EPODOC&CC=EP&NR=2710018B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20211229&DB=EPODOC&CC=EP&NR=2710018B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BLANCO APARICIO, Carmen</creatorcontrib><creatorcontrib>PASTOR FERNÁNDEZ, Joaquín</creatorcontrib><creatorcontrib>RODRÍGUEZ HERGUETA, Antonio</creatorcontrib><creatorcontrib>ÁLVAREZ ESCOBAR, Rosa María</creatorcontrib><creatorcontrib>MARTÍN HERNANDO, Jose Ignacio</creatorcontrib><creatorcontrib>RIESCO FAGUNDO, Rosario Concepción</creatorcontrib><creatorcontrib>CEBRIÁN MUÑOZ, David Álvaro</creatorcontrib><creatorcontrib>GARCÍA GARCÍA, Ana Belén</creatorcontrib><title>MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS</title><description>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2021</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDydXQO8neOdPbxdFZw9vcN8A_1cwlWcAxWCAjyD3H19FPw9vRzDHZV8PTz8HTyDPEPCuZhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfGuAUbmhgYGhhZOhsZEKAEAQ8MmlQ</recordid><startdate>20211229</startdate><enddate>20211229</enddate><creator>BLANCO APARICIO, Carmen</creator><creator>PASTOR FERNÁNDEZ, Joaquín</creator><creator>RODRÍGUEZ HERGUETA, Antonio</creator><creator>ÁLVAREZ ESCOBAR, Rosa María</creator><creator>MARTÍN HERNANDO, Jose Ignacio</creator><creator>RIESCO FAGUNDO, Rosario Concepción</creator><creator>CEBRIÁN MUÑOZ, David Álvaro</creator><creator>GARCÍA GARCÍA, Ana Belén</creator><scope>EVB</scope></search><sort><creationdate>20211229</creationdate><title>MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS</title><author>BLANCO APARICIO, Carmen ; PASTOR FERNÁNDEZ, Joaquín ; RODRÍGUEZ HERGUETA, Antonio ; ÁLVAREZ ESCOBAR, Rosa María ; MARTÍN HERNANDO, Jose Ignacio ; RIESCO FAGUNDO, Rosario Concepción ; CEBRIÁN MUÑOZ, David Álvaro ; GARCÍA GARCÍA, Ana Belén</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP2710018B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>2021</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>BLANCO APARICIO, Carmen</creatorcontrib><creatorcontrib>PASTOR FERNÁNDEZ, Joaquín</creatorcontrib><creatorcontrib>RODRÍGUEZ HERGUETA, Antonio</creatorcontrib><creatorcontrib>ÁLVAREZ ESCOBAR, Rosa María</creatorcontrib><creatorcontrib>MARTÍN HERNANDO, Jose Ignacio</creatorcontrib><creatorcontrib>RIESCO FAGUNDO, Rosario Concepción</creatorcontrib><creatorcontrib>CEBRIÁN MUÑOZ, David Álvaro</creatorcontrib><creatorcontrib>GARCÍA GARCÍA, Ana Belén</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>BLANCO APARICIO, Carmen</au><au>PASTOR FERNÁNDEZ, Joaquín</au><au>RODRÍGUEZ HERGUETA, Antonio</au><au>ÁLVAREZ ESCOBAR, Rosa María</au><au>MARTÍN HERNANDO, Jose Ignacio</au><au>RIESCO FAGUNDO, Rosario Concepción</au><au>CEBRIÁN MUÑOZ, David Álvaro</au><au>GARCÍA GARCÍA, Ana Belén</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS</title><date>2021-12-29</date><risdate>2021</risdate><abstract>There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS |
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