MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS

There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or...

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Hauptverfasser: BLANCO APARICIO, Carmen, PASTOR FERNÁNDEZ, Joaquín, RODRÍGUEZ HERGUETA, Antonio, ÁLVAREZ ESCOBAR, Rosa María, MARTÍN HERNANDO, Jose Ignacio, RIESCO FAGUNDO, Rosario Concepción, CEBRIÁN MUÑOZ, David Álvaro, GARCÍA GARCÍA, Ana Belén
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:There is provided compounds of formula I, wherein R1, R2a, R2b, R2c, X, Y, Z, R3 and ring A/B have meanings given in the description, and pharmaceutically-acceptable esters, amides, solvates or salts thereof, which compounds are useful in the treatment of diseases in which inhibition of a protein or lipid kinase (e.g. PI3-K, particularly class I PI3K, PIM family kinase and/or mTOR) is desired and/or required, and particularly in the treatment of cancer. The invention also relates to combinations containing such compounds.