AMINE DERIVATIVES AS POTASSIUM CHANNEL BLOCKERS

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases,...

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Bibliographische Detailangaben
Hauptverfasser:	MOULD, JORGEN, PAUL, DHARAM, DONINI, CRISTINA, HARVEY, ANDREW, SINGH, RAJINDER, COOKE, RACHEL, JEANCLAUDE-ETTER, ISABELLE, MOLETTE, JEROME, KUCHEL, NATHAN, COLOVRAY, VERONIQUE, CROSSMAN, JULIA, BOMBRUN, AGNES, AVERY, THOMAS, RIPPER, JUSTIN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.