Process for the preparation of pharmaceutical compositions comprising febuxostat in the form of tablets

The invention relates to a process for the preparation of pharmaceutical compositions comprising the steps of: a.1) mixing or blending powders comprising febuxostat and at least one pharmaceutically acceptable excipient in solid form using convection mixers or blenders at least until a homogeneous m...

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Bibliographische Detailangaben
Hauptverfasser: MUNOZ RUIZ, ANGEL JOSE, GIBAJA RUIZ, MANUEL FRANCISCO, JURADO SANCHEZ, FRANCISCO, MARTIN SAIZ, PABLO
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The invention relates to a process for the preparation of pharmaceutical compositions comprising the steps of: a.1) mixing or blending powders comprising febuxostat and at least one pharmaceutically acceptable excipient in solid form using convection mixers or blenders at least until a homogeneous mixture is obtained, optionally mixing or blending the previous mixture with further excipients in solid form; or alternatively a.2) mixing or blending powders comprising febuxostat with at least one disintegrating agent in solid form until a homogeneous mixture is obtained, optionally mixing or blending the previous mixture with further excipients in solid form, wherein the w/w % of disintegrating agents is not lower than 8 % of the pharmaceutical composition; and b) compressing the mixture of step (a) into tablets.