SERINE/THREONINE KINASE INHIBITORS

Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

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Bibliographische Detailangaben
Hauptverfasser:	BOYD, STEVEN, DEMEESE, JASON, BLAKE, JAMES F, GARREY, RUSTAM, MOHR, PETER J, REN, LI, SCHWARZ, JACOB, SIEDEM, CHRISTOPHER S, CHICARELLI, MARK JOSEPH, KAUS, ROBERT J, THOMAS, ALLEN A, MARLOW, ALLISON L, GAUDINO, JOHN J, WENGLOWSKY, STEVEN MARK, CHEN, HUIFEN, WALLACE, ELI, KOLAKOWSKI, GABRIELLE R
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.