Process for obtaining olopatadine and intermediates

Process for obtaining olopatadine and intermediates

Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR 1 , wherein R 1 is C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl, aryl, or heterocycle; or NR 2 R 3 , wherein R 2 and R 3 , independently from each other, are C 1 -C 7 alkyl, aryl, or...

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Bibliographische Detailangaben
Hauptverfasser: LORENTE BONDE-LARSEN, ANTONIO, MATEOS BURON, LYDIA, SILVIA GUISOSOLA, LUIS OCTAVIO, GUTIERREZ FUENTES, LUIS GERARDO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Olopatadine can be obtained by means of a process comprising hydrolysis of a compound of general formula (II), wherein Y is OR 1 , wherein R 1 is C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl, aryl, or heterocycle; or NR 2 R 3 , wherein R 2 and R 3 , independently from each other, are C 1 -C 7 alkyl, aryl, or R 2 and R 3 together with the nitrogen atom to which they are bound form a heterocycle of 3 to 7 members, obtained by means of a process comprising reacting the corresponding ester or amide of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid with a suitable Wittig reagent, in the presence of a base in a reaction medium comprising an organic solvent.