1-(Pyridin-2-yl)-3-(quinolin-4-yl)urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3) inhibitors for the treatment of neurodegenerative diseases
The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the tr...
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| creator | VAN GAALEN, Marcel HORNBERGER, Wilfried TURNER, Sean, Colm BAKKER, Margaretha, Henrica, Maria HOFT, Carolin MACK, Helmut |
| description | The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3 , and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3 activity using the compounds. |
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BAKKER, Margaretha, Henrica, Maria ; HOFT, Carolin ; MACK, Helmut</creator><creatorcontrib>VAN GAALEN, Marcel ; HORNBERGER, Wilfried ; TURNER, Sean, Colm ; BAKKER, Margaretha, Henrica, Maria ; HOFT, Carolin ; MACK, Helmut</creatorcontrib><description>The present invention relates to novel heterocyclic compounds of formula I wherein the variables are as defined in the claims or the description, which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), compositions containing the compounds, their use for preparing a medicament for the treatment of a medical disorder susceptible to the treatment with a compound that modulates, preferably inhibits, the activity of glycogen synthase kinase 3 , and methods of treatment of medical disorders susceptible to treatment with a compound that modulates glycogen synthase kinase 3 activity using the compounds.</description><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 1-(Pyridin-2-yl)-3-(quinolin-4-yl)urea derivatives and related compounds as glycogen synthase kinase 3 (GSK-3) inhibitors for the treatment of neurodegenerative diseases |
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