BICYCLIC COMPOUNDS AS PIM INHIBITORS

The invention relates to bicyclic compounds of formula 2' and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutic...

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Bibliographische Detailangaben
Hauptverfasser:	JACKSON, CLAIRE L.M, CEE, VICTOR J, RUMFELT, SHANNON, NIXEY, THOMAS, LEE, MATTHEW, HERBERICH, BRADLEY, RZASA, ROBERT M, PETTUS, LIPING H, LANMAN, BRIAN, A, WU, BIN, BISWAS, KAUSTAV, REED, ANTHONY B, TASKER, ANDREW, CHAVEZ JR., FRANK, WURZ, RYAN, WANG, HUI-LING
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The invention relates to bicyclic compounds of formula 2' and salts thereof. In some embodiments, the invention relates to inhibitors or modulators of Pim-1 and/or Pim-2, and/or Pim-3 protein kinase activity or enzyme function. In still further embodiments, the invention relates to pharmaceutical compositions comprising compounds disclosed herein, and their use in the prevention and treatment of Pim kinase related conditions and diseases, preferably cancer.