Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors

Aminothiazolidine and aminotetrahydrothiazepine derivatives as BACE 1 inhibitors

A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl...

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Hauptverfasser: ITOH, NAOHIRO, SUZUKI, SHINJI, YASUI, KEN, KOBAYASHI, NAOTAKE, YUKIMASA, AKIRA, KANDA, YASUHIKO, UEDA, KAZUO, SAKAGUCHI, GAKU, KORIYAMA, YUJI, HORI, AKIHIRO, KATO, AKIRA, HARAGUCHI, HIDEKAZU
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A composition having BACE 1 inhibitory activity containing a compound represented by the general formula (I): wherein ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; E is lower alkylene; X is S, O, or NR 1 ; R 1 is a hydrogen atom or lower alkyl; R 2a , R 2b , R 3a , R 3b , R 4a and R 4b is each independently a hydrogen atom, halogen, or hydroxy etc.; n and m are each independently an integer of 0 to 3; n+m is an integer of 0 to 3; R 5 is a hydrogen atom or substituted lower alkyl; its pharmaceutically acceptable salt, or a solvate thereof.