HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES

The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of us...

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Bibliographische Detailangaben
Hauptverfasser: LIU, GANG, BROOKS, CLINTON, A, JIANG, LEI, CHEN, CHRISTINE, HIU-TUNG, SHULTZ, MICHAEL, CHO, YOUNG SHIN
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The present teachings relate to compounds of Formula (I): and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein. The present teachings also provide methods of preparing compounds of Formula (I) and methods of use compounds of Formula (I) in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.