ENGINEERING MULTIFUNCTIONAL AND MULTIVALENT MOLECULES WITH COLLAGEN XV TRIMERIZATION DOMAIN

ENGINEERING MULTIFUNCTIONAL AND MULTIVALENT MOLECULES WITH COLLAGEN XV TRIMERIZATION DOMAIN

The invention relates generally to a new trimerization domain useful for developing multifunctional and multivalent complexes. Particularly, the invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XV protein, and their use...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SANZ ALCOBER, LAURA, CUESTA MARTINEZ, ANGEL, SAINZ PASTOR, NOELIA, ALVAREZ VALLINA, LUIS
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The invention relates generally to a new trimerization domain useful for developing multifunctional and multivalent complexes. Particularly, the invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XV protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes.