BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS

BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS

The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceuticall...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: STUPPLE, PAUL ANTHONY, STORER, ROBERT IAN, BROWN, ALAN DANIEL, MARRON, BRIAN EDWARD, WEST, CHRISTOPHER WILLIAM, DE GROOT, MARCEL JOHN, RYCKMANS, THOMAS, RAWSON, DAVID JAMES, SWAIN, NIGEL ALAN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to sulfonamide derivatives, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z1, Ra, Rb, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.