RECOMBINANT SINGLE-CHAIN ANTIBODY FRAGMENT NEUTRALIZING THE CYTOLYTIC ACTIVITY OF VAGINOLYSIN

RECOMBINANT SINGLE-CHAIN ANTIBODY FRAGMENT NEUTRALIZING THE CYTOLYTIC ACTIVITY OF VAGINOLYSIN

Recombinant antibody single chain fragment (scFv) was obtained from hybridoma 9B4 (DSM ACC2991) cells using genetic engineering methods. The protein was purified and its specificity to vaginolyzin from G. vaginalis has been shown. The invention examples demonstrate the possibility to use scFv for th...

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Hauptverfasser: ZVIRBLIENE, AURELIJA, PLECKAITYTE, MILDA, MISTINIENE, EDITA, PESLIAKAS, JONAS HENRIKAS, ZVIRBLIS, GINTAUTAS
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Recombinant antibody single chain fragment (scFv) was obtained from hybridoma 9B4 (DSM ACC2991) cells using genetic engineering methods. The protein was purified and its specificity to vaginolyzin from G. vaginalis has been shown. The invention examples demonstrate the possibility to use scFv for therapy and prevention purposes of pathology induced by G. vaginalis infection.