IRE-1 INHIBITORS

Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agent...

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Bibliographische Detailangaben
Hauptverfasser: ZENG, Qingping, PATTERSON, John, Bruce, ZUBOVICS, Zoltan, YANG, Yun, WADE, Warren, Stanfield, WU, Zhipeng, TORO, Andras
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.