METHOD FOR GENERATING BIOLOGICALLY FRIENDLY, THREE-DIMENSIONAL OBJECTS OR SURFACES USING LASER RADIATION, SUCH OBJECTS, USE OF SAME AND STARTING MATERIAL FOR THE METHOD

Producing three-dimensional self-supporting and/or substrate-supported molded bodies or structures on surfaces, comprises solidifying a liquid to a pasty organic or organically modified material comprising at least one component containing compounds exhibiting an organic group that is polymerizable...

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Hauptverfasser: STICHEL, THOMAS, PROBST, JOERN, HOUBERTZ-KRAUSS, RUTH, BEYER, MATTHIAS
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Producing three-dimensional self-supporting and/or substrate-supported molded bodies or structures on surfaces, comprises solidifying a liquid to a pasty organic or organically modified material comprising at least one component containing compounds exhibiting an organic group that is polymerizable by two- or multi-photon polymerization and/or compounds exhibiting at least one biocompatible, biodegradable or bioresorbable group, inside a bath of this material in a site-selective manner using two- or multi-photon polymerization. Producing three-dimensional self-supporting and/or substrate-supported molded bodies or structures on surfaces, comprises solidifying a liquid to a pasty organic or organically modified material comprising at least one component containing compounds exhibiting an organic group that is polymerizable by two- or multi-photon polymerization and/or compounds exhibiting at least one biocompatible, biodegradable or bioresorbable group, with a condition that the material comprises both the organic group that is polymerizable by two- or multi-photon polymerization and the biocompatible, biodegradable or the bioresorbable group, inside a bath of this material in a site-selective manner using two- or multi-photon polymerization. Independent claims are also included for: (1) producing a hydrocarbon compound of formula (R 1> 2>-CHR 2> 1>-O-C(O)-CR 3> 1>=CH 2) (IV), comprising reacting a hydrocarbon compound of formula (R 1> 2>-CHR 2> 1>OH) with a hydrocarbon compound of formula (R 4>O-C(O)-CR 3> 1>=CH 2) under conditions that shift the reaction equilibrium towards the product; and (2) a three-dimensional self-supporting and/or substrate-supported molded body or three-dimensional surface structure, produced by the above method, exhibiting a spatial surface structure, on which at least one biological component comprising vegetable, animal or human cells, proteins, enzymes, peptides, amino acids, antibodies, DNA or RNA fragments, are present in bonded form. R 3> 1> : H or CH 3; R 1> 2>CHR 2> 1>(derived from R 1> 2>-CHR 2> 1>OH) : (a) monosaccharides, preferably aldo- or ketopentoses -hexoses or -heptoses (having at least one free OH, where OH groups that are not free are present in protected form), or dimeric, oligomeric or polymeric carbohydrates (containing at least one aldo- or ketopentoses -hexoses or -heptoses), (b) monomeric, oligomeric or polymeric sugar alcohols (obtainable by reducing aldehyde or ketone group of the molecules of (a), or (c