IRE-1A Inhibitors

The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

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Bibliographische Detailangaben
Hauptverfasser:	LONERGAN, DAVID GREGORY, PALLAI, PETER V, PATTERSON, JOHN BRUCE, ZENG, QINGPING, FLYNN, GARY A
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention relates to compounds which directly inhibit IRE-1± activity, and which are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.