Substituted 4-aminocyclohexane derivatives
Substituted 4-aminocyclohexane derivatives (I) and their stereoisomers or their mixtures, free compounds and/or salts are new, where (I) excludes 4-(dimethylamino)-1-methyl-4-p-tolylcyclohexyl acetate. Substituted 4-aminocyclohexane derivatives of formula (I) and their stereoisomers or their mixture...
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Zusammenfassung: | Substituted 4-aminocyclohexane derivatives (I) and their stereoisomers or their mixtures, free compounds and/or salts are new, where (I) excludes 4-(dimethylamino)-1-methyl-4-p-tolylcyclohexyl acetate. Substituted 4-aminocyclohexane derivatives of formula (I) and their stereoisomers or their mixtures, free compounds and/or salts are new, where (I) excludes 4-(dimethylamino)-1-methyl-4-p-tolylcyclohexyl acetate. Either Y 1>, Y1a, Y 2>, Y2a, Y 3>, Y3a, Y 4>, Y4a : H, F, Cl, Br, I, CN, NO 2, CHO, R 0>, C(=O)R 0>, C(=O)H, -C(=O)-OH, -C(=O)OR 0>, C(=O)NH 2, C(=O)NHR 0>, C(=O)N(R 0>) 2, OH, OR 0>, -OC(=O)H, -OC(=O)R 0>, -OC(=O)OR 0>, -OC(=O)NHR 0>, -OC(=O) N(R 0>) 2, -SH, -SR 0>, -SO 3H, -S(=O) 1 - 2-R 0>, -S(=O) 1 - 2NH 2, -NH 2, -NHR 0>, -N(R 0>) 2, -N +>(R 0>) 3, -N +>(R 0>) 2O ->, -NHC(=O)R 0>, -NHC(=O)OR 0>, NHC(=O)-NH 2, -NHC(=O)-NHR 0>or -NHC(=O)N(R 0>) 2, preferably -H, -F, -Cl, -CN or 1-8C-aliphate; or Y 1>Y1a, Y 2>Y2a, Y 3>Y3a, Y 4>Y4a : (=O); Q : R 0>, -C(=O)-R 0>, -C(=O)OR 0>, -C(=O)NHR 0>, -C(=O)N(R 0>) 2or -C(=NH)-R 0>; R 0> : 1-8C-aliphate, 3-12C-cycloaliphate, aryl, heteroaryl, 1-8C-aliphate-3-12C-cycloaliphate, 1-8C-aliphate-aryl, 1-8C-aliphate-heteroaryl, 3-8C-cycloaliphate-1-8C-aliphate, 3-8C-cycloaliphate-aryl or -3-8C-cycloaliphate-heteroaryl, where the: aliphate is optionally saturated, optionally substituted aliphatic hydrocarbon, cycloaliphate is optionally saturated, optionally substituted alicyclic, mono- or multicyclic 3-8C-hydrocarbon (where the H atoms of the aliphate or cycloaliphate are one or more times substituted by F, Cl, Br, I, CN, -NO 2, -CHO, =O, -R 0>, -C(=O)R 0>, -C(=O)H, -C(=O)OH, -C(=O)OR 0>, -C(=O)NH 2, -C(=O) NHR 0>, -C(=O)N(R 0>) 2, -OH, -OR 0>, -OC(=O)H, -OC(=O)R 0>, -OC(=O)OR 0>, -OC(=O)NHR 0>, -OC(=O)N(R 0>) 2, -SH, -SR 0>, -SO 3H, -S(=O) 1 - 2-R 0>, -S(=O) 12NH 2, -NH 2, -NHR 0>, -N(R 0>) 2, -N +>(R 0>) 3, -N +>(R 0>) 2O ->, -NHC(=O)R 0>, -NHC(=O)OR 0>, -NHC(=O)NH 2, -NHC(=O)-NHR 0>, -NH-C(=O)N(R 0>) 2, -Si(R 0>) 3or -PO(OR 0>) 2), aryl is carbocyclic ring system with at least an aromatic ring and without heteroatoms (which are optionally further condensed with further saturated, partially unsaturated or aromatic ring system and optionally substituted in any position), or heteroaryl is 5-7 membered cyclic aromatic residue containing 1-5 heteroatoms of O, N or S (where the heterocycle is optionally substituted in any position and is a part of a bi or polycyclic system) (where the aryl or heteroaryl is one or more t |
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