PROCESS FOR PREPARING PHARMACEUTICAL COMPOUNDS AND INTERMEDIATE COMPOUNDS

PROCESS FOR PREPARING PHARMACEUTICAL COMPOUNDS AND INTERMEDIATE COMPOUNDS

The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-α-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PANDUR, ANGÉLA, MOLNÁR, ENIK, GREGOR, TAMÁS, NYULASI, BÁLINT, RUZSICS, GYÖRGY, PORCS-MAKKAY, MÁRTA, BRODA, JUDIT, VOLK, BALÁZS, BARKÓCZY, JÓZSEF, DEBRECZENI, JÓZSEF, SZENT-KIRÁLLYI, ZSUZSANNA, MEZEI, TIBOR, NAGY, KÁLMÁN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The object of the present invention is a process for preparing the 2-acetoxi-5-(2-fluor-α-cyclopropyl-carbonyl-benzyl)-4,5,6,7-tetrahydro-4H-thieno[3,2-c]pyridine (prasugrel) of the formula (I). The process starts from crystalline 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI). Further objects of the present invention are two novel crystalline forms of 5-trityl-4,5,6,7-tetrahydro-thieno[3,2-c]pyridine of the formula (VI) and the use thereof for preparing the compound of the formula (V) and process preparing thereof.