PROBE FOR DETECTING POLYMORPHISMS IN THE K-ras GENE, AND USE THEREOF

The present invention provides a polymorphism detection probe that can identify a different polymorphism in a K-ras gene easily with high reliability and use of the polymorphism detection probe. The polymorphism detection probe is a probe for detecting a polymorphism in a K-ras gene that is a disease-related gene, including at least one of oligonucleotides (P1), (P2), (P3), (P1'), (P2'), and (P3'): (P1) a 11- to 50-mer oligonucleotide that is composed of a base sequence complementary to a base sequence including the 220th to 230th bases in SEQ ID NO: 1 and has a base complementary to the 230th base in its 5' end region; (P1') an oligonucleotide composed of a base sequence complementary to the oligonucleotide (P1); (P2) a 15- to 50-mer oligonucleotide that is composed of a base sequence complementary to a base sequence including the 220th to 234th bases in SEQ ID NO: 1 and has a base complementary to the 234th base in its 5' end region; (P2') an oligonucleotide composed of a base sequence complementary to the oligonucleotide (P2); (P3) a 17- to 50-mer oligonucleotide that is composed of a base sequence complementary to a base sequence including the 220th to 236th bases in SEQ ID NO: 1 and has a base complementary to the 236th base in its 5' end region; and (P3') an oligonucleotide composed of a base sequence complementary to the oligonucleotide (P3).