PROCESSES FOR THE PREPARATION OF 5-LIPOOXYGENASE ACTIVATING PROTEIN INHIBITORS AND THEIR INTERMEDIATES

PROCESSES FOR THE PREPARATION OF 5-LIPOOXYGENASE ACTIVATING PROTEIN INHIBITORS AND THEIR INTERMEDIATES

The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethy...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: TROUW, LEONTINE SASKIA, GARCIA, SANDRINE, KENNEDY, ANDREW, HARLING, SANDRA JANE, HUTCHINSON, JOHN HOWARD, TURNER, PETER GRAHAM, MASON, ANDREW MCMURTRIE, WALLIS, CHRISTOPHER JOHN, GRAHAM, JONATHAN PAUL, KEEL, TREVOR RAYMOND, SCOTT, MARK SIMON, TATENO, YUICHI, WILLACY, ROBERT DAVID, HERMITAGE, STEPHEN ANDREW, HENLEY, NICHOLAS PAUL, SMITH, NEIL MICHAEL, STOCK, NICHOLAS SIMON, CRAWFORD, CLAIRE FRANCES
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention provides processes useful for preparing 5-lipoxygenase activating protein (FLAP) inhibitors and their intermediates. In particular, processes for preparing 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, the anhydrous Form C polymorph of sodium 3-[3-(tert-butylsulfanyl)-1-[4-(6-ethoxy-pyridin-3-yl)benzyl]-5-(5-methyl-pyridin-2-yl-methoxy)-1H-indol-2-yl]-2,2-dimethyl-propionate, and intermediates useful in said processes are provided.