METHOD FOR INDUCTION OF DIFFERENTIATION OF STEM CELLS INTO HEPATOCYTES

METHOD FOR INDUCTION OF DIFFERENTIATION OF STEM CELLS INTO HEPATOCYTES

Disclosed are: a gene transduction method for use in the induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocytes effectively; stem cells into each of which a gene useful fo rthe induction of the differentiation into hepatocytes is introduced; and hepatocytes pro...

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Bibliographische Detailangaben
Hauptverfasser: MIZUGUCHI, Hiroyuki, FURUE, Miho, INAMURA, Mitsuru, KAWABATA, Kenji
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Disclosed are: a gene transduction method for use in the induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocytes effectively; stem cells into each of which a gene useful fo rthe induction of the differentiation into hepatocytes is introduced; and hepatocytes produced from stem cells each having the gene introduced therein. A specific gene can be introduced into stem cells such as ES cells or iPS cells using an adenovirus vector. The effective induction of the differentiation into hepatocytes can be achieved by introducing the gene. Specifically, the effective induction of the differentiation of stem cells such as ES cells or iPS cells into hepatocyts can be achieved by introducing at least one gene selected from HEX gene, HN-F4A gene, HNF6 gene and SOX17 gene into the stem cells.