Process for isolating the antiviral agent [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

Process for isolating the antiviral agent [1S-(1alpha, 3alpha, 4beta)]-2-amino-1,9-dihydro-9-[4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one

The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophob...

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Bibliographische Detailangaben
Hauptverfasser: CHAN, YEUNG, Y, PATEL, SUNIL, S, PATEL, RAMESH, N, SHI, ZHONGPING, KUCERA, DAVID, J, BANERJEE, AMIT, STOJANOVIC, MILAN, VEMISHETTI, PURUSHOTHAM, THOTTATHIL, JOHN, RIJHWANI, SUSHIL, K, LEWIS, CHARLES, KRISHNAMURTY, DHILEEPKUMAR, LIANG, JING, POLNIASZEK, RICHARD, EVANS, JEFFREY, M, CHEN, CHUNG-PIN, H, ZHOU, MAOTANG X, WANG, SHAOPENG, PENDRI, YADAGIRI, R, SINGH, AMBARISH, K
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention refers to a method for isolating entecavir or an entecavir intermediate from a diluted mixture, the diluted mixture comprising entecavir and water or a mixture comprising an entecavir intermediate and other process reagents comprising: (a) adsorbing the diluted mixture onto a hydrophobic resin bed; (b) washing the resin bed with water to remove salt; and (c) eluting the entecavir or entecavir intermediate from the resin bed with an organic solvent.