Skin and muscle-targeted gene therapy by pulsed electrical field

The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.

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Bibliographische Detailangaben
Hauptverfasser: HOFMANN, GUNTER, A, ZHANG, LEI, RABUSSAY, DIETMAR, TONNESSEN, ARNT, DEV, NAGENDU B, NOLAN, EDWARD, WIDERA, GEORG
Format: Patent
Sprache:eng ; fre ; ger
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Beschreibung
Zusammenfassung:The present invention describes an in vivo method, using pulsed electric field to deliver therapeutic agents into cells of the skin and muscle for local and systemic treatments. In particular, therapeutic agents include naked or formulated nucleic acid, polypeptides and chemotherapeutic agents.