Therapeutic pro-apoptotic BH3-like molecules and methods for generating and/or selecting the same

The present invention relates generally to therapeutic molecules which are useful for modulating apoptosis in a target cell or cell population. More particularly, the present invention provides therapeutic agents which inhibit pro-survival molecules and which are capable of inducing or facilitates apoptosis of a target cell or cell population such as cancer cells. Further provided are methods for generating or selecting the therapeutic molecules and pharmaceutical compositions comprising the therapeutic molecules.