PHOSPHORAMIDATE AND/OR PHOSPHONAMIDGROUP MODIFIED MACROMOLECULES

PHOSPHORAMIDATE AND/OR PHOSPHONAMIDGROUP MODIFIED MACROMOLECULES

A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x>=1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1)(OR1'), and/or at least one x-fold (x>=1) chemoselectively i...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HACKENBERGER, Christian, VALLEE, Robert, DEL SIGNORE, Giuseppe, WILKENING, Ina, SERWA, Remigiusz
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x>=1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1)(OR1'), and/or at least one x-fold (x>=1) chemoselectively incorporated phosphonamide group of general formula (Ia), NPO(R1)(OR1'). R1 and R1' is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n>=1, Cn-alkyl chains with n>=1; functionalized Cn-alkyl chains with n>=1, aryls, heteroaryl, silyl, lipids, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups. R1 and R1' can be identical to or different from one another.