Process for the preparation of S-fluoromethyl-6,9-difluoro-11-hydroxy-16-methyl-17-propionyloxy-3-oxo-androsta-1,4-diene-17-carbothioate and intermediates

The present invention relates to a process for the preparation of steroidal 17²-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17²-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introd...

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Bibliographische Detailangaben
Hauptverfasser:	GADAKAR, Maheshkumar, Gore, Vinayak G, POKHARKAR, K, WAKCHAURE, Vikas
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	The present invention relates to a process for the preparation of steroidal 17²-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17²-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.