Non-invasive system for the determination of analytes in body fluids

A system (10) for determining the concentration of an analyte in at least one body fluid in body tissue (52) comprises an infrared light source (20), a body tissue interface (34), a detector (58), and a central processing unit (78). The body tissue interface (34) is adapted to contact body tissue (52) and to deliver light (14) from the infrared light source (20) to the contacted body tissue (52). The detector (58) is adapted to receive spectral information corresponding to infrared light (56) transmitted through the portion of body tissue (52) being analyzed and to convert the received spectral information into an electrical signal indicative of the received spectral information. The central processing unit (78) is adapted to compare the electrical signal to an algorithm built upon correlation with the analyte in body fluid, the algorithm adapted to convert the received spectral information into the concentration of the analyte in at least one body fluid.